Effect of bowel resection on lower esophageal high pressure zone and reflux status in rhesus monkeys

Abstract

Giles et al. [5] in 1969 and Caste11 and Harris [2] in 1970 have shown that gastrin has a tonic effect on the lower esophageal high pressure zone (HPZ). The physiologic significance, if any, of the influence of hormones on the gastroesophageal junction remains the subject of much controversy. Massive bowel resection increases gastric acid secretion, presumably by a humoral mechanism. Recently serum gastrin has been shown to be significantly elevated under these circumstances in both dog [16] and man [ 141. We investigated the effect of altering the humoral milieu by 50% small bowel resection on the HPZ pressure and functional integrity of the lower esophagus. The animal model used was the subhuman primate Macaca mulatta.