Abstract
Purpose: Previous studies have suggested that obesity can affect the oocyte yield, embryo quality and pregnancy rates following IVF. In vitro maturation differs from IVF in several ways including lack of controlled ovarian stimulation, oocyte retrieval when majority are expected to be still immature, and possibly different endometrial environment due to short secretory phase and the lack of exposure to supraphysiologic estrogen levels. Therefore female obesity can affect IVM and IVF cycles differentially. This study aims to assess the effect of female obesity on IVM outcomes in women without polycystic ovarian syndrome. Methods: Retrospective chart review of 125 women who underwent an IVM cycle during a 5 year period. Women were divided to four categories based on Body Mass Index (BMI) according to the World Health Organization classification. Procedural and clinical outcomes were compared across different BMI categories. Independent effect of BMI on the odds of achieving a live birth was assessed using a multivariate logistic regression model. Results: The numbers of cumulus corona complexes, in vivo matured and immature oocytes collected, metaphase two oocytes available for fertilization, good quality embryos available for transfer and embryos transferred were not statistically significantly different across BMI categories. Likewise, in vitro maturation rate of immature oocytes, fertilization rate, embryo implantation, clinical pregnancy and live birth rates were similar across the groups. BMI category did not have an independent effect after adjusting for possible confounders in the regression model. Conclusions: BMI does not seem to affect IVM outcomes
Highlights
Female fertility is affected by body weight; both underweight and overweight women are more likely to suffer from infertility than women with normal body weight [1,2]
Body Mass Index (BMI) category did not have an independent effect after adjusting for possible confounders in the regression model
Female obesity can be expected to differentially affect In Vitro Maturation (IVM) outcome than In Vitro Fertilization (IVF) outcome
Summary
Female fertility is affected by body weight; both underweight and overweight women are more likely to suffer from infertility than women with normal body weight [1,2]. Studies investigating the effect of obesity on IVF outcome have yielded contradictory results [3,4,6,7]. In Vitro Maturation (IVM) treatment involves collection of oocytes relatively earlier in the follicular phase when the majority is expected to be still immature and does not require Controlled Ovarian Hyperstimulation (COS) [10,11]. Female obesity can be expected to differentially affect IVM outcome than IVF outcome. A former study investigating effect of BMI on IVM outcome in women with Polycystic Ovarian Syndrome (PCOS) reported similar outcomes in different BMI categories [12]. Metabolic profiles and estrogenisation status of women with and without PCOS can differ, modifying an affect of BMI on IVM outcomes. Present study aims to assess the affect of BMI on outcome of IVM cycles undertaken for other indications than PCOS in order to provide further insight
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