Abstract
Objective To discuss the influence of body mass change on curative effects of chemotherapy on elderly patients with advanced gastric cancer. Methods A total of 100 elderly patients with advanced gastric cancer treated from January 2012 to June 2017 in Henan Provincial People’s Hospital were selected. Oxaliplatin combined with tegio regimen (SOX regimen) and oxaliplatin combined with fluorouracil and calcium folinate regimen (mFOLFOX4 regimen) were given to patients for chemotherapy according to individual conditions. All the patients were grouped according to the increase or decrease of body weight during chemotherapy. Forty-eight patients with increased body weight were selected as observation group, and 52 patients with decreased body weight were selected as control group. After 2 cycles of chemotherapy, the chemotherapy effect and adverse reactions of the two groups were compared. Results After chemotherapy, there was no significant difference in objective remission rate between the two groups (P 0.05). The main adverse reactions of the two groups were myelosuppression, gastrointestinal reactions and neurotoxicity. The incidence of anemia in control group was higher than that in observation group (P 0.05). Conclusions During the course of chemotherapy, increase in body mass will result in decrease in the incidence of anemia, improvement in immunity and progression-free survival. Key words: Elderly patients; Advanced gastric cancer; Chemotherapy; Weight change
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