Effect of blood glucose fluctuation on retinal microangiopathy in type 2 diabetes mellitus and the treatment measures

Abstract

Objective To investigate the effect of blood glucose fluctuation on retinal microangiopathy in type 2 diabetes mellitus and therapeutic measures. Methods Ninety type 2 diabetic patients with retinal microangiopathy treated in hospital from January 2016 to December 2017 were selected. The patients were divided into two groups randomly. The patients in the control group were treated with triamcinolone acetonide and the patients in the study group were treated with compactopril. The differences of blood glucose indexes between the two groups were compared. The best corrected visual acuity score (BCVA) before and after treatment and the therapeutic effects of the two groups were observed. Results The mean fluctuation amplitude of blood glucose (MAGE), the maximum fluctuation of blood glucose(LAGE) and the standard deviation of blood glucose (SDBG) in the control group were significantly higher than those in the study group (P 0.05), and the BCVA score of the study group was significantly higher than that of the control group (P<0.05) after treatment (P<0.05). The quality of life of the study group was significantly higher than that of the control group (P<0.05). Conclusions The fluctuation of blood glucose is closely correlated with the development of type 2 diabetic patients with retinal microangiopathy, the doctors should control the change of blood glucose in time and take effective treatment measures to promote vision recovery and improve the quality of life of patients. Key words: Blood glucose fluctuation; Type 2 diabetes mellitus; Retinal microangiopathy; Treatment measures