Abstract
IntroductionThis retrospective study investigated the implications of changes in blood parameters and cellular immune function in patients with Coronavirus Disease 2019 (COVID-19).MethodsRecords were reviewed of 85 patients admitted with COVID-19 between February 4 and 16, 2020. The primary outcome was in-hospital death.ResultsFourteen patients died. The baseline leukocyte count, neutrophil count and hemoglobin was significantly higher in non-survivors compared with survivors, while the reverse was true of lymphocyte count, platelet, PaO2/FiO2, CD3+ count and CD4+ count. The percentage of neutrophil count > 6.3×109/L in death group was significantly higher than that in survival group, and multivariate logistic regression showed neutrophil count > 6.3×109/L was independently associated with mortality. However, there were not significant difference in IgG, IgM, IgA, C3, C4 and the percentage of IgE > 100 IU/ml between the death group and survival group. Areas under the receiver operating characteristic curves of the following at baseline could significantly predict mortality: leukocyte, neutrophil, lymphocyte, CD3+ and CD4+ counts.ConclusionsFor hospitalized patients with COVID-19, lymphocyte, CD3+ and CD4+ counts that marked decrease suggest a poor outcome. Admission neutrophil count > 6.3 ×109/L is independently associated with mortality. At admission, leukocyte, neutrophil, lymphocyte, CD3+ and CD4+ counts should receive added attention.
Highlights
OPEN ACCESSCitation: Fu Y-Q, Sun Y-L, Lu S-W, Yang Y, Wang Y, Xu F (2020) Effect of blood analysis and immune function on the prognosis of patients with Coronavirus Disease 2019 (COVID19)
The baseline leukocyte count, neutrophil count and hemoglobin was significantly higher in non-survivors compared with survivors, while the reverse was true of lymphocyte count, platelet, PaO2/FiO2, CD3+ count and CD4+ count
Areas under the receiver operating characteristic curves of the following at baseline could significantly predict mortality: leukocyte, neutrophil, lymphocyte, CD3+ and CD4+ counts
Summary
Records were reviewed of 85 patients admitted with COVID-19 between February 4 and 16, 2020. The Ethics Committee of Children’s Hospital, Chongqing Medical University (Institutional Review Board of Children’s Hospital, Chongqing Medical University) approved this retrospective cohort study. The study population comprised patients with COVID-19 pneumonia, who had been admitted to the ward of the Third Batch of Chongqing Medical Aid Team in Wuhan city of Hubei province in China, from 4 February 2020 to 16 February 2020. The patients in this study were confirmed to have SARS-CoV-2 infection by real-time reverse transcription polymerase chain reaction (RT-PCR) assay, from nose and throat swab samples. Patients with any of the following were excluded from this study: death due to natural causes rather than viral infection; immunodeficiency; or with long-term use of glucocorticoids or immunosuppressants before admission
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