Abstract
BackgroundBotulinum toxin injection on the masticatory muscle induces the osteopenic condition on the ipsilateral condyle. Bisphosphonate suppresses bone resorption and is used to treat osteopenic or osteoporotic condition. This study aimed to evaluate the effect of bisphosphonate administration on prevention of condylar resorption and botulinum toxin A-induced disuse osteopenia in rats.ResultsThe volume of the condyle and bone volume/tissue volume (BV/TV, %) showed a strong tendency towards statistical significance (p = 0.052 and 0.058). Trabecular thickness (Tb.Th, mm) and trabecular number (Tb.N, 1/mm) were significantly smaller in the Botox group than in the other groups (p < 0.05). The volume of the condyle and BV/TV in the bisphosphonate 100 and bisphosphonate 200 groups showed similar values when compared with the control group.ConclusionBisphosphonate administration after botulinum toxin A injection in the masticatory muscles appears to prevent condyle resorption and botulinum toxin-induced disuse osteopenia in rats.
Highlights
Botulinum toxin injection on the masticatory muscle induces the osteopenic condition on the ipsilateral condyle
Botulinum toxin A (BTX-A) is most widely used among the seven types of toxins produced by Clostridium species [2]
The purpose of this study was to evaluate the effect of bisphosphonate administration on the prevention of condylar resorption and botulinum toxin A-induced disuse osteopenia in rats
Summary
Botulinum toxin injection on the masticatory muscle induces the osteopenic condition on the ipsilateral condyle. Bisphosphonate suppresses bone resorption and is used to treat osteopenic or osteoporotic condition. This study aimed to evaluate the effect of bisphosphonate administration on prevention of condylar resorption and botulinum toxin A-induced disuse osteopenia in rats. Botulinum toxin A (BTX-A) is most widely used among the seven types of toxins produced by Clostridium species [2]. BTX-A is used for cosmetic purpose in patients with masseter muscle hypertrophy [3]. BTX-A is used for reducing pain in temporomandibular disorders [4]. Tsai et al reported that a decrease in muscle volume leads to a decrease in mandibular bone mass [5]. An experimental study on rabbits reported significant decrease in bone quality and quantity in the condylar head at 4 weeks after botulinum toxin injection (BTI).
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