Abstract
The effects of isoxsuprine and epinephrine on prostaglandin biosynthesis in the pregnant human myometrial microsomal fraction was determined. The epinephrine analog isoxsuprine displayed the stimulatory effect of L-epinephrine, especially at low concentrations. Above 0.1 mM it shows a reversible inhibitory effect on PG-synthetase activity. The prostaglandin F/E ratio shifts in a characteristic manner. The data support the hypothesis that a “motor substance”, possibly a specific prostaglandin, may accumulate in the myometrial strips during exposure to isoxsuprine. It is suggested that the maximum beta-agonist effectiveness might be expected if the PG-synthetase induction were negligible and the inhibitory action pronounced at the low concentrations of the beta-mimetic compound used to suppress premature uterine activity.
Published Version
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