Abstract
In the current decade, a growing body of evidence has proposed the correlation between diet and cognitive function or dementia in the ageing population. This study was designed to appraise discoveries from the randomized controlled trials to confirm the effects of berry-based supplements or foods on cognitive function in older adults. PubMed/MEDLINE, Cochrane Central Register of Controlled Trials, Web of Science, Scopus, EMBASE, Google Scholar, and ProQuest as well as SID, Magiran, and Iranmedex electronic databases were explored for human interventional studies up to March 2021. In total, eleven articles were identified using frozen blueberry (n = 4 studies), blueberry concentrate (n = 2), beverage (n = 3), capsule (n = 1), extract and powder (n = 1). These studies had been performed among older people with no recognized cognitive impairment or mild cognitive impairment (MCI). The primary outcomes included global cognitive function, psychomotor function, learning and memory, working memory capacity, executive functions, and brain perfusion/activity. To our knowledge, this is the first systematic review of available clinical trials on the effects of berry-based supplements and foods on cognitive performances as well as brain perfusion parameters among the elderly with normal cognition or MCI. Existing evidence concludes that berry-based supplements and foods have beneficial effects on resting brain perfusion, cognitive function, memory performance, executive functioning, processing speed, and attention indices.
Highlights
In the current decade, a growing body of evidence has proposed the correlation between diet and cognitive function or dementia in the ageing population
This activation was related to an improved expression of the growth factor brain-derived neurotrophic factor (BDNF), which has been widely involved in the preservation of neuronal function through aging
Due to the lack of systematic review in this regard, the present review study was planned to review recent indications for the beneficial properties of berry-based supplements and foods on cognitive components in the elderly and middle-aged healthy subjects or subjects with mild cognitive impairment (MCI)
Summary
Description Adult or old subjects with healthy cognition or mild cognitive impairment Whole Berries/Berry-based Food/Berry Extract/Berry Supplement Any comparator Outcomes regarding at least one of the following indices: episodic memory, long-term memory, short-term memory, working memory, executive function, psychomotor reaction time, attention Randomized controlled clinical trial with a crossover or parallel design. There is some evidence suggesting that polyphenols from berries may be presenting a multiplicity of impacts on the aging brain comprising antioxidant properties, vascular consequences, gluco-regulation, neuro-synthesis, and gut microbiota modifications[25,36,37,38,39,40,41] Berry fruits and their chemical ingredients facilitate signaling pathways including those involved in cell longevity as well as increasing neuroplasticity, neurotransmission, and neuronal calcium homeostasis, all of which reduce the age-related decline in behavior[40]. Berry supplementation was revealed to persuade stimulation of a multifunctional transcription factor most especially raised throughout the consolidation of short-term to long-term memory in the hippocampus This activation was related to an improved expression of the growth factor brain-derived neurotrophic factor (BDNF), which has been widely involved in the preservation of neuronal function through aging. Due to the lack of systematic review in this regard, the present review study was planned to review recent indications for the beneficial properties of berry-based supplements and foods on cognitive components in the elderly and middle-aged healthy subjects or subjects with MCI
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