Effect of Bauhinia variegata Leaf Extract in Diabetic Cardiomyopathy

Abstract

Diabetes mellitus is a chronic metabolic disorder associated with development of micro and macro vascular diabetic complications. According to World Health Organization cardiovascular disease causes up to 65% of deaths among diabetic population. The present work was designed to study effect of Bauhinia variegata, a medicinal plant described in Ayurveda for its medicinal benefits in diabetic cardiomyopathy. Alcoholic extract of Bauhinia variegata leaf (AlcE) was prepared by Soxhlet extraction technique and was standardized using HPTLC. Male Sprague Dawley rats were injected with streptozotocin (55 mg/kg, i.p.) for induction of diabetes. After 42 days of diabetes induction, the animals were grouped and treated with alcoholic extract at dose of 250, 500 and 1000 mg/kg by oral route for next 28 days. At the end of treatment, plasma and heart tissue were collected for evaluation of various parameters. AlcE at 1000 mg/kg significantly reduced plasma glucose as compared to diabetic control animals. AlcE at dose of 500 and 1000 mg/kg significantly (P<0.001) reduced elevated level of creatine kinase‐MB, lactate dehydrogenase and aspartate transaminase in plasma as compared to diabetic animals. AlcE treatment prevented cardiac tissue from oxidative damage, it significantly reduced the elevated level of malonyl dialdehyde at dose of 500 and 1000 mg/kg whereas it significantly increased the level of antioxidant enzymes at dose of 1000 mg/kg (P<0.001). Present study showed that Bauhinia variegata leaf extract has significant effect in management of diabetic cardiomyopathy.This abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal.