Antioxidative Effects of Natural Products on Diabetic Cardiomyopathy.

Bingdi Yan,Jin Ren,Junduo Wu,Junling Yang,Rong Gao,Qinghua Zhang,Fenglian Zhao

doi:10.1155/2017/2070178

Abstract

Diabetic cardiomyopathy (DCM) is a common and severe complication of diabetes and results in high mortality. It is therefore imperative to develop novel therapeutics for the prevention or inhibition of the progression of DCM. Oxidative stress is a key mechanism by which diabetes induces DCM. Hence, targeting of oxidative stress-related processes in DCM could be a promising therapeutic strategy. To date, a number of studies have shown beneficial effects of several natural products on the attenuation of DCM via an antioxidative mechanism of action. The aim of the present review is to provide a comprehensive and concise overview of the previously reported antioxidant natural products in the inhibition of DCM progression. Clinical trials of the antioxidative natural products in the management of DCM are included. In addition, discussion and perspectives are further provided in the present review.

Highlights

Diabetes mellitus (DM) is one of the most common metabolic disorders, encountered in human populations worldwide
No natural product has been used in clinical trials targeting diabetic cardiomyopathy (DCM), several have been used in clinical trials in patients with DM, even as traditional medicines for the treatment of DM for many years
The capability of the natural products in enhancing serum antioxidative activity and reducing serum oxidative stress may be beneficial for the amelioration of DCM

Summary

Introduction

Diabetes mellitus (DM) is one of the most common metabolic disorders, encountered in human populations worldwide. Recent studies have proposed that DCM would be a result of a longlasting process in which the myocardium is affected at a very early stage by metabolic changes prior to the diagnosis of DM [5] This process progresses rapidly by the incidence of myocardial ischemia [5]. The clinical features of DCM include diastolic dysfunction at an early stage and systolic dysfunction at a late stage which result in reduced left ventricular function, early heart failure, myocardial fibrosis, and death [6]. This procedure is not accompanied by hypertension or coronary heart disease. We summarize the previous findings and provide perspectives and indications for future studies

Role of Oxidative Stress in DCM

Signaling Pathways in the Regulation of Oxidative Stress in DCM

Antioxidative Role of Natural Products in DCM

Clinical Trials

Findings

Conclusions