Effect of azithromycin sequential therapy on inflammatory cytokines and humoral immune function in the treatment of children with mycoplasma pneumonia

Abstract

Objective To explore the effect of azithromycin sequential therapy on inflammatory cytokines and humoral immune function in the treatment of children with mycoplasma pneumonia. Methods 342 children with mycoplasma pneumonia were divided into control group(168 cases) treated with erythromycin sequential therapy and observation group (174 cases) treated with azithromycin sequential therapy based on the random number table.The changes of inflammatory cytokines and humoral immune function were recorded and compared. Results The levels of interleukin 4(IL-4), interleukin 6(IL-6), C-reactive protein(CRP) and tumor necrosis factor-α(TNF-α) had no significant differences between the two groups before accepting different treatments (P>0.05). The decreased levels of IL-4, IL-6, CRP and TNF-α of the observation group after treatment were greater than the control group(t=10.913, 11.047, 9.919, 53.207, all P 0.05). After treatment, the decrease of IgM and IgG between the two groups had significant differences (t=3.178, 3.034, all P<0.01). Conclusion Azithromycin sequential therapy for the treatment of children with mycoplasma pneumonia has better clinical efficacy than erythromycin sequential therapy, which can improve inflammatory cytokines index and regulate humoral immune function.It has considerable value in the clinical application. Key words: Pneumonia, mycoplasma; Azithromycin; Inflammatory cytokines; Immunity, body fluid; Children; Administer drug