Abstract
Objective:The present study is on line with our previous studies evaluating the influence of ATP-binding cassette transporter A1 (ABCA1) gene polymorphisms on the lipid variables of Greek student-nurses. The current study was undertaken to (1) estimate the influence of variant(s) such as rs2066715 (V825I), R219K, R1587K, I883M of ABCA1 gene on lipid variables and (2) evaluate the effect of all four ABCA1 polymorphisms on common demographic parameters.Methods:The study population involved 432 unrelated nurses (86 men) who were genotyped for ABCA1 polymorphisms and correlated according to lipid variables [total cholesterol (TC), triglycerides (TGs), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C) and apolipoprotein (apo) A] and demographic parameters (age, gender, BMI, waist circumference).Results:According to lipid variables concentration there was no difference between genotypes and alleles of V825I, R219K and I883M polymorphisms. The LDL-C concentration was 13% lower in RR compared with RK genotype (100.7 vs. 113.9 mg/dl, p=0.013) of R1587K gene polymorphism. In regression analysis the effects of age, gender and only R1587K gene polymorphism on LDL-C concentrations were proved significant. Additionally, LDL-C was increased (by 1.29 mg/dl on average) by every year of increase of age. Moreover, females had lower LDL-C concentrations as compared with males.Conclusion:Findings suggested that only R1587K polymorphism of ABCA1 gene was associated with lipid variables, age, and gender of Greek nurses. These findings may be helpful in assessing the risk factors for premature coronary heart disease and distinct individuals with lower/higher atherosclerotic burden.
Highlights
Genes that influence protein function, which mediate cholesterol metabolism, are the most likely to influence the1874-1924/16 2016 Bentham Open234 The Open Cardiovascular Medicine Journal, 2016, Volume 10 plasma lipid and lipoprotein concentrations
The study population involved 432 unrelated nurses (86 men) who were genotyped for ATP-binding Cassette Transporter A1 (ABCA1) polymorphisms and correlated according to lipid variables [total cholesterol (TC), triglycerides (TGs), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C) and apolipoprotein A] and demographic parameters
According to lipid variables concentration there was no difference between genotypes and alleles of V825I, R219K and I883M polymorphisms
Summary
Genes that influence protein function, which mediate cholesterol metabolism, are the most likely to influence the1874-1924/16 2016 Bentham Open234 The Open Cardiovascular Medicine Journal, 2016, Volume 10 plasma lipid and lipoprotein concentrations. ABCA1 protein plays a critical role in the inhibition of macrophage foam cell creation and atherosclerosis by mediating the dynamic transport of intracellular cholesterol and phospholipids to apolipoprotein (apo) A1, the major lipoprotein of the high density lipoprotein (HDL) particle. Numerous ABCA1 gene polymorphisms have been already evaluated, such as R219K, R1587K and I883M (rs2230806, rs2230808 and rs4149313, respectively) [4, 5]. In this study we evaluated (1) the effect of V825I (rs2066715) gene polymorphism ( to already reported R219K, R1587K and I883M) on lipid variables total cholesterol (TC), triglyceride (TG), HDL-C, low density lipoprotein cholesterol (LDL-C) and apolipoprotein (apo) A1 and analysed the possibly correlations between them and (2) the demographic parameters such as age, gender, BMI and waist circumference) in Greek student-nurses
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