Abstract
L-Thyroxine(T4) and triiodothyronine(T3)are iodine-containing hormones produced from thyroglobulin in the thyroid follicular cells. The stimulation of metabolic rate and regulation of growth and development by these hormones appear to be due to their effects on DNA transcription and, thus, protein synthesis. The aqueous extract of vitis vinifera L. was investigated for its effect on hormones in rabbits. The aqueous extract of plant at a dose level of 50µg/rabbit showed highly significant (p<0.05)on levels of hormones T4, TSH but TSH no significant. L-thyroxine sodium treated group showed a highlysignificant increase in T3 and T4 while there was a highly significant decrease in TSH. From the above results, it is concluded for the first time that aqueous vitvs vinifera L. extract offers significant effect of T3, T4 and TSH in this rabbit females compared with control.
Highlights
Vitis vinifera L. is a perennial woody vine native to Asia Minor and introduced in Europe and other continents[1]
It has been demonstrated that the grape leaf hydro- alcoholic extract (GLHE) induces spasmolytic effect on rat uterus precontracted by oxytocine[6] and the same extract induces vasorelaxant effect on rat isolated aorta[7]
The aim of this study was to evaluate the effect of the aqueous extract of Vitis vinifera L.on T3,T4 and Thyroid stimulating hormone (TSH) levels in rabbit females have thyrotoxicosis induced by levothyroxine sodium
Summary
Vitis vinifera L. (grape) is a perennial woody vine native to Asia Minor and introduced in Europe and other continents[1]. The leaves are alternate, palmately lobed, 5-20 cm long and broad. The fruit is a green, known as a grape; in the wild species it is 6 mm diameter and ripens dark purple to blackish with a pale wax bloom;in cultivated plants it is usually much larger, up to 3 cm long, and can be green, red, or purple (black). The species typically occurs in humid forests and streamsides.[2] Different parts of plant, the fruits, used in folk medicine. The leaves of Vitis vinifera (Vitaceae) is used in traditional food (dolmathes) in some Mediterranean countries and in folk medicine used for the treatment of diarrhea and vomiting[4]. Grape leaves with antioxidant activity[4]have been reported to treat chronic venous insufficiency in human[5] and nephrotoxicosis induced by citrinin[6]. It has been demonstrated that the grape leaf hydro- alcoholic extract (GLHE) induces spasmolytic effect on rat uterus precontracted by oxytocine[6] and the same extract induces vasorelaxant effect on rat isolated aorta[7]
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