Effect of Apricot kernel on Some Hematological,Histological and Biochemical Parameters in CCl4-induced Liver Injury in rats

Abstract

The purpose of the present study was to find out the effect of apricot kernel on carbon tetrachloride (CCl4) induced liver injury in male albino rats. To achieve this purpose and to explain, the histological, hematological and biochemical parameters were included. Thirty male albino rats were used and randomly divided to in to three groups. The first group represented control group which received normal diet and intraperitoneal injection with oil (0.5 ml/kg). The second group injected with CCl4(1 ml/kg), represented the CCl4(1 ml/kg)model,the third groupwere treated like the second group with 15%/ day apricot kernelfor a month . The apricot kernel extracts treated group showed significant differences in AST, ALT, ALP, direct bilirubin, , GSH, liver SOD, WBC, LYM and PLT when compared to CCl4 treated rats. In the current study histological section through the liver of control rats showed normal architecture of hepatocytes.Although Paraffin section of the rat liver treated with CCl4 most of the hepatocytes were degenerated, congestion of blood and inflammatory leukocyte infiltration were observed,the results showed that CCl4 injection caused significant alterations in histological and biochemical parameters but our study showed that the apricot kernel administration showed improvement of histological analysis for four weeks (March to April 2015).