Abstract
Background Children with Down's syndrome are more liable to vitamin D deficiency. Treating this deficiency with supplements is associated with the risk of intoxication. Aim The study is aimed at comparing the effect of two exercise intensities on the modulation of vitamin D and parathormone levels in children with DS. Methods Forty-four DS male children aged from 8 to 12 years participated in the study. They were assigned randomly into two equal groups. Group I received high-intensity treadmill aerobic exercises, and group II received moderate-intensity T-AE, three times per week for three months. The blood samples were collected from both groups before the intervention, after one month of intervention, then after three months of intervention to assess serum 25(OH)D and PTH levels. Results Repeated measure MANOVA revealed that the high-intensity T-AE induced a significant increase in 25(OH)D after one month and after three months while it significantly decreased PTH only after three months. Moderate-intensity T-AE had a nonsignificant effect on both hormones. Conclusion The current study concluded that the high-intensity T-AE improved both vitamin D and parathormone serum levels after three months of intervention.
Highlights
Down’s syndrome (DS) is the commonest chromosomal disorder that causes mental retardation
It was noticed that vitamin D deficiency is a common health problem even among children of sunshiny areas such as Jeddah, Kingdom of Saudi Arabia, which is associated with health problems such as rickets
There were no significant differences between the two groups regarding the mean of sun exposure and vitamin D intake during the study period, age, Body mass index (BMI) percentile, or physical activity level
Summary
Down’s syndrome (DS) is the commonest chromosomal disorder that causes mental retardation. It occurs in 1 in 700– 1000 live births [1]. Children with Down’s syndrome are more liable to vitamin D deficiency. Treating this deficiency with supplements is associated with the risk of intoxication. Aim. The study is aimed at comparing the effect of two exercise intensities on the modulation of vitamin D and parathormone levels in children with DS. Forty-four DS male children aged from 8 to 12 years participated in the study They were assigned randomly into two equal groups. The current study concluded that the high-intensity T-AE improved both vitamin D and parathormone serum levels after three months of intervention
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