Abstract
The effect of antimycin A on hormone-stimulated lipolysis in vitro was investigated using noradrenaline, cyclic 3',5'-AMP and theophylline. The titration curve of antimycin against noradrenaline-stimulated lipolysis was sigmoidal, like the behaviour of antimycin on the respiratory chain of mitochondria. Antimycin A was found to antagonize the lipolytic effect of both cyclic 3',5'-AMP and theophylline. The range of active concentrations against the different drugs, was very similar. These data confirm that hormone-induced lipolysis needs ATP, generated by oxidative phosphorylation, both before and after cyclic 3',5'-AMP synthesis.
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