Effect of antidepressant on negative emotion and quality of life in patients with mental disorder caused by cerebrovascular disease

Abstract

Objective To study the effect of antidepressant in improving negative emotion and life quality of patients with mental disorder caused by cerebrovascular disease. Methods 112 patients with mental disorder caused by cerebrovascular disease in our hospital from June, 2015 to June, 2016 were randomly divided into experimental group (n=56) and control group (n=56). The patients in the experimental group were treated with escitalopram, while the patients in the control group were treated with paroxetine. Hamilton Depression Scale (HAMD), Loeweistein occupational therapy cognitive assessment (LOTCA), Karnofsky performance score (KPS), quality of life core scale (QLQ-C30) were analyzed before and 6 weeks after treatment respectively. Results There were no statistically significant differences in HAMD, LOTCA, KPS, and QLQ -C30 scores between the experimental group and the control group before treatment (P>0.05); 6 weeks after treatment, HAMD score in the experimental group were significantly lower than that in the control group [(13.28±2.12) vs.(19.66±2.85), P<0.05], LOTCA, KPS scores in the experimental group were significantly higher than those in the control group [(98.76±5.05) vs.(73.38±7.44), (85.52±7.21) vs.(71.36±6.84); P<0.05], and the scores of body function, psychological function, social function, and overall quality of life in QLQ-C30 in the experimental group were significantly higher than those in the control group (P<0.05). Conclusion Antidepressant escitalopram indeed improve negative emotion and quality of life of patients with mental disorder caused by cerebrovascular disease. Key words: Antidepressant; Cerebrovascular disease; Mental disorder; Negative emotion; Quality of life