Abstract
One hundred and twenty patients with epilepsy who had been on various anticonvulsant drugs were selected for the study of their lipid profile. We found a significant increase in serum levels of triglyceride, total cholesterol, HDLc and VLDLc in patients receiving combination therapy of either Phenytoin and Phenobarbitone or Phenytoin and Carbamazepine or Phenytoin alone. Patients receiving Carbamazepine alone had significant increase in serum levels of triglyceride and VLDLc but no significant changes in serum levels of total cholesterol & HDLc in this group. A significant correlation between duration of anticonvulsant therapy and lipid profile was established. Our results indicated the long-term use of anticonvulsant therapy significantly raises total cholesterol level and therefore cholesterol should be regularly checked in patients undergoing such treatment.
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