Abstract

Objective To evaluate the effect of difterent concentrations of antibiotics on antibacterial effects and physical properties of conventional glass-ionomer cements (GICs).Methods Fuji IX GIC was used as a control.Different concentrations of three antibiotic mixtures,ciprofloxacin,metronidazole and minocycline,were added to powdered GIC (Fuji Ⅸ) to obtain concentration ratios of 1.5%,3.0% and 4.5%.The antibacterial activity of each GIC was evaluated against Streptococcus mutans using agar-diffusion methods and scanning electron microscopy (SEM).The compressive strength were measured and compared with those of control samples.Results All tested groups showed a significantly greater inhibition with growth of the selected bacteria in comparison to the control groups (P < 0.05).However,the antibiotics had significantly lower compressive strength than the control group (P <O.05).Conclusions The GIC-containing antibiotics are effective in inhibiting S.mutans.However,the antibiotics compromised the mechanical properties of the cement. Key words: Antibiotics ; Glass ionomer cement; S.mutans ; Compressive strength

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