Abstract
Objective To evaluate the effect of difterent concentrations of antibiotics on antibacterial effects and physical properties of conventional glass-ionomer cements (GICs).Methods Fuji IX GIC was used as a control.Different concentrations of three antibiotic mixtures,ciprofloxacin,metronidazole and minocycline,were added to powdered GIC (Fuji Ⅸ) to obtain concentration ratios of 1.5％,3.0％ and 4.5％.The antibacterial activity of each GIC was evaluated against Streptococcus mutans using agar-diffusion methods and scanning electron microscopy (SEM).The compressive strength were measured and compared with those of control samples.Results All tested groups showed a significantly greater inhibition with growth of the selected bacteria in comparison to the control groups (P ＜ 0.05).However,the antibiotics had significantly lower compressive strength than the control group (P ＜O.05).Conclusions The GIC-containing antibiotics are effective in inhibiting S.mutans.However,the antibiotics compromised the mechanical properties of the cement. Key words: Antibiotics ; Glass ionomer cement; S.mutans ; Compressive strength
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