Abstract
Objective Oral health status may play a role in Helicobacter pylori eradication. Because adequate secretion of saliva promotes oral health, the aim of the study was to assess the effect of salivary secretion on the efficacy of H pylori eradication from the stomach. Study design The study involved 90 H pylori–positive subjects with duodenal ulcer (68 men, 22 women, aged 20-70 years) in whom saliva was collected under basal conditions for 45 min before antibacterial treatment began. They received no drugs for at least 3 days prior to saliva collection. A 7-day course of either of 2 eradication regimens—omeprazole, amoxicillin, and tinidazole (OAT); or omeprazole, amoxicillin, and clarithromycin (OAC)—was used. The efficacy of eradication therapy was evaluated 30 days after its completion. Results The efficacy of H pylori eradication from the stomach (per protocol analysis) was 77.5% in the group of subjects treated with OAT and 81.6% with OAC. Combined analysis of both groups (OAT + OAC) showed reduced salivary secretion in subjects with eradication failure (0.395 ± 0.266 vs 0.25 ± 0.176 mL/min, P = .042). A similar outcome was obtained when the OAT group was analyzed separately (0.436 ± 0.316 vs 0.211 ± 0.216 mL/min, P = .022), but in the OAC group the difference was not significant. In the combined analysis, the efficacy of eradication therapy was lower in women than in men (52.9% vs 86.9%, P = .005). In women, it corresponded to salivary secretion (successful eradication 0.337 ± 0.133 mL/min, unsuccessful eradication 0.180 ± 0.144 mL/min, P = .043); whereas in men, the difference was not significant (successful eradication 0.405 ± 0.282 mL/min, unsuccessful eradication 0.321 ± 0.186 mL/min). Conclusion Low salivary secretion may contribute to the decrease in efficacy of H pylori eradication from the stomach, at least in subjects treated with certain drug regimens.
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call