Effect of anti vascular endothelial growth factor injection on neovascularization of retina in proliferative diabetic retinopathy

Abstract

Background Vascular endothelial growth factor (VEGF) has captured the attention of many investigators involved with ocular neovascularization. Aim This work aimed to evaluate the effect of anti-VEGF injection on neovascularization of the retina in cases of proliferative diabetic retinopathy (PDR) by fundus fluorescein angiography. Patients and methods This prospective study was carried out on 30 eyes of thirty patients aged from 24 to 66 years old, both sexes, diagnosed with PDR who were treated with anti-VEGF injection (Lucentis, Eylea) for 3 months. The neovessels at disc (NVD) or elsewhere in the retina (NVE) were compared before and after injection (after 1, 2 months) by fundus fluorescein angiography. Results There is a significant good effect of anti VEGF injection on NVD after 1 and 2 months of injection. There is significant good effect of anti VEGF injection on NVEs after 1 and 2 months of injection (P<0.001). There is no significant difference between effect of Eylea and effect of Lucentis on NVDs and NVEs with insignificant P value of 0.243 and 0.662 after 1 month of injection, and insignificant P value 0.182, and 0.480 after 2 months of injection. Conclusions Injection with anti VEGF has a good effect on neovascularisations of retina at disc or elsewhere and can treat it so injection not only for macular oedema but also to treat neo vessels in PDR.