Abstract
A study was conducted to determine whether or not circulating gonadotropin is required for follicular ovulability after the follicles have grown to an ovulable state, using PMS and anti- PMS serum (APS) in hypophysectomized immature female rats. Immature rats hypophysectomized on day 22 received PMS iv on day 26. When follicles developed to an ovulable state (60–72 hr after PMS), APS was given iv at various times during this period to neutralize circulating PMS. HCG was used as an ovulating hormone to test the follicular ability to ovulate. When hCG was given simultaneously with APS, almost all of the rats ovulated. When hCG injection was delayed 3 hr after APS, the mean number of ova per ovulating rat had already decreased significantly to 14.4 as compared to 23.3 for the corresponding control group, although a similar percentage of ovulation was obtained (80 vs 86). No ovulation occurred by hCG 9 hr after APS administration. It was concluded that PMS is needed continuously in the circulating blood to ma...
Published Version
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