Abstract
The effects of 4 constituents of gastrointestinal medications and calcium citrate on the absorption of phenytoin were examined in vitro using an experimental model based on the everted segment of rat intestine. Bismuth carbonate increased phenytoin absorption by 28.2%; magnesium trisilicate reduced absorption (−6.2%) as also did light kaolin (−60.2%), activated dimethicone (−71.3%) and calcium citrate (−77.2%). The latter 3 values were significantly different from control absorption values ( P < 0.05). Agents which decrease phenytoin absorption markedly in vitro may be implicated in poor phenytoin bioavailability in vivo.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
