Abstract
Phenytoin as a sesame oil suspension or emulsion was administered orally to beagle dogs to study improvement of its bioavailability. The absorption of phenytoin by the digestive tract was better when it was given as a sesame oil suspension or emulsion than as a powder. With the dose amount of sesame oil and water fixed, the absorption of phenytoin from the emulsion was greater than that from the oil suspension, although the difference was not significant. Therefore, the absorption of phenytoin was not affected significantly by emulsifying the sesame oil. Its absorption corresponded not to the amount of water given with the dose amount of sesame oil fixed, but to the dose amount of sesame oil with the dose amount of water fixed, reaching maximum when the ratio of sesame oil to water was 1:3. Study of the influence of the type of oil in the emulsion on the absorption by the digestive tract showed that absorption was best with cod-liver oil, followed by sesame oil, and then oleic acid.
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