Effect of Anesthetic Drugs on Lysosomal Enzymes in the Rat

Abstract

SummaryA comparison of the effects of carbon tetrachloride with those of chloroform and of three other halogenated anesthetic compounds on the concentrations of two lysosomal enzymes in the liver and plasma of rats is presented. In the liver, all of the treatments resulted in an increase in beta-glucuronidase and all except carbon tetrachloride resulted in increased acid phosphatase activity. The plasma levels of acid phosphatase increased after all treatments while an increase in plasma beta-glucuronidase was associated with all treatments except halothane. The degree of increased acid hydrolase levels varied between the treatments both in the liver and in the plasma.