Abstract
To evaluate the effects of andiroba oil on the periodontitis in rats. The periodontitis was induced by the placement of cotton ligatures around the cervix of the second upper molars on fifteen rats, and waiting fifty days. The animals were randomly distributed into three groups: saline group, andiroba oil group and meloxican group, differentiated by substance used in the treatment of periodontitis. The groups received the respective substance by gavage for seven days, after the periodontitis induced. It was analyzed the score of inflammatory cells and the measurement from the cemento-enamel junction to the bone crest. The andiroba oil group (p=0.008) and meloxican group (p=0.0347) show a less score of inflammatory cells than saline group, however there weren't difference between them (p=0.2754). Regarding the analysis of measurement from the cemento-enamel junction to the bone crest, there was no difference between groups studied (p=0.3451). Andiroba oil decreased the quantity of inflammatory cells, however, it didn't have an effect on the measurement of alveolar bone loss, like the treatment with Meloxican®.
Highlights
The oral cavity is a natural reservoir of thousands of micro-organisms with a high potential for infection[1]
This colonization can progress to the formation of periondontal disease that is characterized as an infectious disease that results in the destruction and degradation of periodontal tissues by the local action of periodontopathogenic microorganisms[3]
These microorganisms release substances that lead to progressive destruction of structures supporting the teeth: the periodontal ligament, the alveolar bone and gingival tissues[4,5]
Summary
The oral cavity is a natural reservoir of thousands of micro-organisms with a high potential for infection[1]. When associated with a poor oral hygiene and / or indiscriminate use of antibiotics can cause a differentiated of the microbiota on this area of the body[1,2] This colonization can progress to the formation of periondontal disease that is characterized as an infectious disease that results in the destruction and degradation of periodontal tissues by the local action of periodontopathogenic microorganisms[3]. The periodontitis, a chronic inflammatory oral disease, affects a major part of world’s population characterized by localized or generalized bone resorption, reaching about 10-15% of the adult population[6] These rates are very high in patients with diabetes[7], hypertension[8] or smoking[9]
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