Effect of Anchomanes difformis Ethanol Root Extract on Electrolyte Level of Testosterone-Induced Benign Prostatic Hyperplasia in Wistar Rats

Abstract

Benign prostatic hyperplasia is the most common male benign proliferative disease; characterized by overgrowth of prostatic tissue around the urethra constricting the urethral opening. The study investigated the effect of Anchomanes difformis ethanol root extract on electrolyte level of testosterone induced benign prostatic hyperplasis in Wistar rats. Forty two matured male Wistar rats weighing 150-180 g were divided into 6 groups of 7 animals each and acclimatized for 7 days. Prostate was induced with 5mg/kg of testosterone for 21 days. Two animals were sacrificed and blood collected for PSA assay. Groups 4, 5 and 6 were treated with 1000 mg/kg, 500mg/kg and 250 mg/kg of the extract respectively. The testosterone induced group 3 was treated with finesteride standard control and group 2 represented the BPH induced control group, while group 1 served as normal control. The administration of the extract lasted for 21 days. The results obtained showed a non significant (P>0.05) increase in Na+ (mmol/L) concentration at 1000mg/kg of plant extract Bph C group vs normal control, while the finesteride group had no effect on Na+ concentration treated with Bph C group. There was a significant (p<0.05) reduction in Cl concentration at 1000mg/kg vs 5mg/kg of testosterone and 5mg/kg and finesteride, with no significant (p>0.05) effect at 500 mg/kg Vs normal control. For K+ (mmol/L) concentration in plant treated groups, 1000 mg/kg increase significantly at 250 mg/kg. Conclusively, the results suggested, Anchomanes difformis root extract has the potential to maintain serum electrolytes in benign prostatic hyperplasia management induced by testosterone and diarrhea patients.