Abstract
The regulation of fatty acid composition by ammonium ions and amino acids was studied in Streptomyces fradiae, a tylosin producer. The quantity of branched-chain fatty acids in S. fradiae cells decreased significantly in cultures cultivated in a medium containing high concentrations of ammonium ions, in which the biosynthesis of tylosin was also strongly inhibited. Amino acids stimulating the tylosin production most pronouncedly, also substantially modified the composition of cell fatty acids.
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