Abstract
RECENT evidence has indicated that the synthesis of DNA viruses is prevented by specific DNA inhibitors while the synthesis of RNA viruses is not affected1–3. On this basis, therefore, experiments were undertaken to determine if aminopterin (4 amino-pteroylglutamic acid), a folic acid antagonist, would block the replication of the murine salivary gland virus (MSGV) in tissue culture. In the presence of adenine and glycine the antifolic drugs have been shown specifically to block the formation of DNA in mammalian cell cultures3. Under such conditions the antifolics will inhibit replication of DNA but not RNA viruses2,3.
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
