Abstract
Puromycin, an inhibitor of protein synthesis with general growth inhibitory properties, was found to inhibit replication of influenza virus in tissue culture in low concentrations without destroying all met abolic activity of the tissue. The aminonucleoside of puromycin, reported to be as effective as the complet e compound against trypanosomes, was inactive as an inhibitor of the virus. Evidence suggests the mechanism of the virus inhibition is probably interference with protein synthesis, and that the antitrypanosomal activity has a different mechanism. Puromycin, an inhibitor of protein synthesis with general growth inhibitory properties, was found to inhibit replication of influenza virus in tissue culture in low concentrations without destroying all met abolic activity of the tissue. The aminonucleoside of puromycin, reported to be as effective as the complet e compound against trypanosomes, was inactive as an inhibitor of the virus. Evidence suggests the mechanism of the virus inhibition is probably interference with protein synthesis, and that the antitrypanosomal activity has a different mechanism.
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