Abstract
This study was carried out to establish the effect of aminophylline (theophylline ethylenediamine) synthetic analogue of theophylline on serum total protein, albumin, iron, total iron binding capacity (TIBC) and transferrin in Wistar rats. The experimental animals were divided into 4 groups of 6 rats each. Group 1 received physiological saline as a placebo and served as a control. Groups II, III, and IV received 2.5 mg/kg, 5.0 mg/kg and 7.5 mg/kg body weight respectively of aminophylline daily for 5 days. Blood obtained from the sacrificed animals 24 hours after the last treatment was transferred into iron-free centrifuge tube, allowed to clot and serum obtained was used for analyzing. The results showed that there was a significant dose dependent increase (P<0.5) in mean serum iron and significant dose dependent decrease (P<0.05) in TIBC and serum transferrin in Wistar rats treated with different concentration of aminophylline when compared with control rats. However, mean values of total protein, and albumin in experimental animals showed no significant difference when compared with the control. The results of this study suggest that acute administration of aminophylline may affect serum iron, transferrin and TIBC levels and the consequences of this effect are discussed in relation to iron transport and erythropoiesis.
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