Abstract
Hypothyroid and hyperthyroid states were induced in rats by drug treatment with propylthiouracil and thyroxine, respectively. The thyroid states were verified by measuring serum thyroxine using a commercial competitive protein-binding technique. A single 109Cd ip injection was then given to three groups: hypo-, eu-, and hyperthyroid. The uptake of 109Cd in liver and kidneys was measured at times ranging from 1 to 120 hr. On a per gram basis, 109Cd uptake in livers and kidneys of hypothyroid rats was significantly greater than that of eu- and hyperthyroid rats, even though there was a dwarfing effect in the hypothyroid group. The transfer of 109Cd from the liver to the kidneys was not affected by the altered thyroid states.
Published Version
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