Abstract
Dialkylaminoalkyl esters of 4,4’-diphenyl propanedicarboxylic acid; 4,4 ’-dibenzyldi- carboxylic acid; 4,4,-diphenybnethanedicarboxylic acid; 4,4 ’-diphenyldicarboxylic acid, and terephthalic acid were prepared as the hydrochlorides and tested for local anesthetic activity on the rabbit cornea and by intradermal injection in the guinea pig.Acute toxicity was studied by intraperitoneal and intravenous injection in mice.No predictable relationship between local anesthetic activity and the size of the dicarboxylic acid nucleus was evident.Toxicity decreased as the methylene groups between the benzene rings was reduced.Two esters appeared to have greater local anesthetic activity and lower toxicity than procaine.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Journal of Pharmaceutical Sciences (Scientific Edition)
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
