Effect of Alpinia officinarum Hance alcohol extracts on primary dysmenorrheal.

Abstract

To study the effect of Alpinia officinarum Hance (A.officinarum) 80% alcohol extract on the primary dysmenorrhea. A.officinarum 80% alcohol extract were enriched by macroporous adsorption resins. Female mice of primary dysmenorrhea model were established by oxytocin induction; the effects of A.officinarum 80% alcohol extract on primary dysmenorrhea were observed by body twist method; and the homogenate level of prostaglandin F2α (PGF2α), prostaglandin E2 (PGE2) and Ca(2+) in the uterus were observed in oxytocin-induced female mice. The writhing frequency of primary dysmenorrhea mice was significantly decreased after treatment of A.officinarum 80% alcohol extract and the level of PGF2α, PGE2 and Ca(2+) in mice uterus was significantly decreased (P<0.05, P<0.01) in groups of mice treated with middle and high dosage of A.officinarum 80% alcohol extract compared with that of model group. These findings suggest that A.Officinarum 80% alcohol extract can significantly relieve primary dysmenorrhea.