Effect of aloe vera on lipid and sugar levels in male rats exposed to high doses of dexamethasone therapy

Abstract

The present study was undertaken to observe the effect of the aqueous leaf extract of Aloe vera gel of the reduction in blood glucose and lipid level in hyperglycemia and hyperlipidemia rats. Twenty four male rats were divided into four groups (6 rats/group) and treated as follows for 28 days.G 1 were intubated orally distal water serving as control while, G2 were administrating of Dexamethason -induced diabetic 1 mg/kg/bw. Intraperitoneally, G3 were administrating of diabetic rats given Dexamethason 1mg/kg/bw. + Aloe vera leaf gel extract (300 mg/kg) using an intragastric tube, G4) were administrating of diabetic rats given Dexamethasone 1 mg/kg/bw. intraperitoneally + Aloe vera leaf gel extract (500 mg/kg) using an intragastric tube, the following criteria were measured sugar levels and blood lipid profile. The findings show that Aloe Vera had a significant decrease influence in serum glucose, cholesterol, TG, and VLDL and a significant decrease HDL. In conclusion, this study mention a new evidence of the role of Aloe Vera on the decreasing glucose, lipid profile.