Effect of aloe vera on antioxidant in male rats exposed to high doses of dexamethasone therapy, and histological on liver and pancreas

Abstract

The present study was undertaken to observe the effect of the aqueous leaf extract of Aloe vera gel of the Antioxidant and histological on liver and pancreas. Twenty_four male rats were divided into four groups (6rats/group) and treated as follows for 28 days.G 1 were intubated orally distal water serving as control while, G2 were administrating of Dexamethason -induced diabetic 1 mg/kg/bw. Intraperitoneally, G3 were administrating of diabetic rats given Dexamethason 1mg/kg/bw. + Aloe vera leaf gel extract (300 mg/kg) using an intragastric tube, G4)were administrating of diabetic rats given Dexamethasone 1mg/kg/bw. intraperitoneally + Aloe vera leaf gel extract (500 mg/kg) using an intragastric tube, the following criteria were measuredAntioxidant and histological on liver and pancreas. The findings show that Aloe Vera had a significant decrease influence in serumAntioxidant (MDA, ACE, and HSP70). In conclusion, this study mentioned a new evidence of the role of Aloe Vera on the decreasing of antioxidant.