Abstract
Combination therapy is considered as a new and effective therapeutic strategy for control of hyperglycemia. The present study aimed to determine the hypoglycemic effect of Afghan Hibiscus sabdariffa L. and Carum Carvi L. hydro-alcoholic extracts either alone or in combination on diabetic rats. Streptozotocin-induced diabetic rats were administered intraperitoneally with hydro-alcoholic extracts of H. sabdariffa (75, 150 and 300 mg/kg), C. carvi (150, 300 and 500 mg/kg) and their combinations for 21 days. The Fasting blood glucose and body weight of rats were determined on 0, 7, 14 and 21st days. The results showed a significant (P<0.0001) hypoglycemic effect of H. sabdariffa extract (75, 150 and 300 mg/kg) on 7, 14 and 21th days, C. carvi extract (500 mg/kg), and their effective doses combination (75:25), especially on 7th day. Only 75 mg/kg of H. sabdariffa had positive effect on body weight loss of diabetic rats (P<0.05). One can conclude that Afghan H. sabdariffa and C. carvi hydro-alcoholic extracts and their combination have a hypoglycemic effect. However, their combinations do not have any synergic effects, so the hypoglycemic effect of H. sabdariffa was much greater and even normalized the blood glucose level.
Highlights
Diabetes mellitus is the most common endocrine disorder, which considered as one of the main causes of death and disability in many countries [1]
The present study aimed to determine the hypoglycemic effect of Afghan Hibiscus sabdariffa L. and Carum Carvi L. hydro-alcoholic extracts either alone or in combination on diabetic rats
The STZ was dissolved in 0.1 M citrate buffer. 72 hours later, diabetes was confirmed by determining the fasting blood glucose (FBG) level
Summary
Diabetes mellitus is the most common endocrine disorder, which considered as one of the main causes of death and disability in many countries [1]. This disorder, which is known as the silent epidemic of the present century, affects many people in the world and its prevalence is increasing. Diabetes mellitus is a group of metabolic diseases, characterized by hyperglycemia as a result of defects in insulin secretion, insulin function, or both [3]. The main cause of diabetic mortality and morbidity is diabetic complications, which resulted from hyperglycemia [4]. The major target of medicinal therapy for diabetes is balancing blood glucose level [5]
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