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Abstract
Objective: The aim of the study was to evaluate the acute effect of the intranasal 17β-estradiol (Aerodiol ®, Servier, Chambray-les-Tours, France) administration on cerebral blood flow (CBF) volume. Methods: Eighteen healthy women who had been natural postmenopausal for at least 1 year were enrolled in the study. We conducted an experimental, randomized, placebo-controlled, crossover, double-blinded study of the acute effect of 17β-estradiol on the internal carotid artery (ICA), vertebral artery (VA) and, CBF volume using color duplex sonography. Results: There were significant increases in the ICA, VA flow volumes and CBF volume after 17β-estradiol administration compared to placebo measurements. However, there was no statistically significant difference in flow velocities or pulsatility indices. Conclusion: Nasal 17β-estradiol administration in postmenopausal women causes significant increases in CBF volume due to its vasodilatatory effect on ICA and VA.
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