Abstract
Isoproterenol, infused into the kidney of unilaterally nephrectomized dogs at doses of 0.26–0.01 μg/kg/min, was tested for its effect on plasma renin activity in the absence and presence of peripheral infusions of adrenoceptor-blocking agents. Neither phonoxybenzamine (4 mg/kg) nor phentolamine (4.4 and 8.8 μg/kg/min) caused a significant reduction in the renin response during isoproterenol infusion. Likewise D-propranolol, at doses of 2.2 and 22 μg/kg/min, also was ineffective in preventing significant increases in plasma renin activity during isoproterenol administration. However, both L- and D,L-propranolol forms of the drug possessing significant β-adrenoceptor activity, consistently prevented isoproterenol-induced changes in plasma renin levels at doses as low as 2.2 and 5.0 μg/kg/min. The data strongly support the theory that isoproterenol-induced renin releases is mediated by β-adrenoceptors. No evidence was obtained to suggest the involvement of α-adrenoceptors in the renin release which occurs during isoproterenol infusion.
Published Version
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