Abstract
The regulation of the numbers of blood lymphocytes seems to be under pituitary control and is mediated by way of the adrenal cortex (Dougherty and White, 1944). In human patients with intact adrenals under administration of ACTH there is a decrease in circulating eosino-philes, a decrease in lymphocytes, and an increase in neutrophiles (Forsham, 1948). Since the decrease in eosinophiles is approximately twice as great as that of lymphocytes, the eosinophiles are a more sensitive indication of adrenal cortical activity than the lymphocytes (Forsham, 1948). The work of Speirs and Meyer (1949) has established that stresses of various kinds will produce a marked decrease in the number of circulating eosinophiles in animals with intact adrenals and in adrenalectomized animals given adrenal cortical hormones. The response reaches a maximum at four hours after injection or stimulation, followed by a return to normal numbers of cells within eight to twelve hours.
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