Abstract
Objective To investigate the changes of immunologic functions and life qualities after the auto-cytokine induced killer (CIK) cells combined with interleukin-2(IL-2) being transfused back to the patients with non-small cell lung cancer (NSCLC). Methods Thirty-eight NSCLC patients were enrolled, and 19 patients received not only chemotherapy and radiotherapy but also adoptive immunotherapy with CIK cells combined with IL-2 compared with the other 19 patients who only accepted radiotherapy and chemotherapy. The changes of immunologic functions and life qualities after the CIK cells combined with IL-2 being transfused back to the patients with NSCLC were observed. Immune targets of the treatment group and control group, such as peripheral blood CD3+, CD4+, CD8+ T cell percentage, ratio of CD4+ /CD8+ and Th1/Th2, were observed at the end and after 3 month of the radiation and chemotherapy. Results Both of the two groups were neither having obvious adverse reactions. After CIK cells combined with IL-2 treatment, the life qualities of patients improved, such as 18 cases of mental improvement, 15 cases of appetite improvement, 12 cases of sleep improvement, and 3 cases of fatigue symptoms improvement. The percentage of CD3+, CD4+ cells in the treatment group increased [(66.39±9.22)% vs (42.98±7.23)%, t=5.45, P=0.00; (32.27±3.75)% vs (26.38±2.51)%, t=5.73, P=0.00], the percentage of CD8+ cells declined [(17.51±1.85)% vs (20.90±2.31)%, t=5.21, P=0.00], the rate of CD4+ /CD8+ increased and the rate of Th1/Th2 obversed [(1.86±0.32) vs (1.27±0.19), t=7.13, P=0.00; (1.15±0.48) vs (0.91±0.30), t=2.42, P=0.02]. There were significant differences between the two groups. Conclusion Adoptive immunotherapy with CIK cells combined with IL-2 is safe in clinical, which can improve the immunologic functions and life qualities of the patients with NSCLC. Key words: Carcinoma, non-small-cell lung; Immunotherapy; Cytokine induced killer cells
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