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Abstract
1. 1. Low xanthine dehydrogenase (LXD) mutant Drosophila melanogaster were fed 0.2% adenine for 7 generations, no adenine for the next 2 generations (relaxed) and 0.2% adenine again for the next 3 generations (rechallenged) to obtain adenine-resistant lines of Drosophila (LXD-adenine). Flies grown without adenine served as LXD-controls. 2. 2. Purines ranked as follows; adenine > adenosine > AMP > inosine > IMP in decreasing order of toxicity to LXD-adenine flies. 3. 3. Addition to ribose to 9N position, or phosphate or carboxy to 6C position of the purine ring alleviated the toxicity. 4. 4. More LXD-adenine offspring survived than did LXD-control offspring rechallenged with adenine.
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