Abstract
In Drosophila melanogaster , the ma-1 (64 + , X chromosome) and the ry (52 + , 3rd chromosome) eye color mutants are deficient in xanthine dehydrogenase (see Glassman, 1962b,for a discussion of these loci). However, incubating extracts of ma-1 and ry flies together elicits xanthine dehydrogenase activity although none was initially present ( Glassman, 1962b). This in vitro complementation suggests that a ry + complementing “factor” in ma-1 extracts and a ma-1 + complementing “factor” in ry extracts react to produce functional enzyme molecules. The nature of these “factors” is not clear. Recently we have discovered lxd (low xanthine dehydrogenase) at a third locus (33 + , 3rd chromosome). These flies have 20 to 25% the xanthine dehydrogenase activity of wild-type ( Keller and Glassman, 1964). This paper is a preliminary report describing the effect of this locus on the ma-1 + complementing factor.
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