Abstract
The effects of acid-base disturbances on plasma phosphorus concentration remain poorly defined. In a previous study, we infused anesthetized mongrel dogs with several mineral and non-mineral acids for one to three hours. HCl and NH4Cl infusions were not associated with changes in plasma phosphorus in contrast to the findings with the organic acids lactic (LA) and beta-hydroxybutyric which increased, and methylmalonic which decreased phosphorus levels. To evaluate these observations further and to gain insight into the mechanism(s) involved we measured plasma phosphorus concentration and renal phosphorus handling in dogs infused with 0.45% NaCl (control), HCl and LA for six hours. In the control group there was no significant change in phosphorus levels whereas the increase in phosphorus concentration for LA was significant after hour four. Although with HCl, phosphorus concentration decreased in the first hour, there was a tendency for an elevation by five hours. Cumulative six hour UpV was significantly lower with HCl than with either LA or NaCl and the data suggest that the infusion of both acids may have blunted the augmentation of phosphorus excretion associated with mild volume expansion. Plasma glucose and insulin measured for three hours showed no significant differences between the groups.
Published Version
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