Abstract
The present study investigated the effects of zolpidem on 5-hydroxytryptamine, dopamine, 5-hydroxyindole acetic acid and homovanillic acid brain levels in rats. Zolpidem was administered by intraperitoneal injection (5 mg kg−1, free base) daily, for periods of up to 28 days. Zolpidem did not modify dopamine, homovanillic acid or 5-hydroxyindole acetic acid levels in brain tissue. However, acute and chronic administrations of zolpidem increased 5-hydroxytryptamine levels. We conclude that at the usual therapeutic dose, zolpidem influences 5-hydroxytryptamine metabolism.
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