Abstract
During the mid breeding season daily administration of 100 i.u. adrenocorticotrophic hormone (ACTH) from Days 13–16 of the oestrous cycle in multiparous, Welsh Mountain ewes (42–51 kg) significantly ( P<0.01) delayed oestrus and decreased ( P<0.01) oxytocin-induced release of 13,14-dihydro-15-keto-prostaglandin (PG)F 2α (PGFM) on Days 14 and 15. In ovariectomized Welsh Mountain ewes (40–50 kg) primed first with progesterone (10 mg day −1 × 6 days) and then oestradiol-17β (500 μg day −1 × 2 days), ACTH (50 i.u.) significantly ( P<0.001) reduced the ability of oxytocin to release PGFM into the peripheral circulation and also reduced oxytocin receptor concentrations in the myometrium ( P<0.05) and endometrium ( P<0.01). We conclude that ACTH can delay oestrus in the ewe by suppressing formation of uterine oxytocin receptors.
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