Effect of abnormal body mass index on outcomes of stroke patients receiving intravenous thrombolysis: A retrospective cohort study and meta-analysis

Abstract

ObjectivesIt is not clear yet if abnormal body mass index affects the outcome of stroke patients receiving intravenous thrombolysis (IVT). We aimed to explore this issue through a retrospective cohort study and meta-analysis. MethodsA total of 955 consecutive patients who received IVT ≤4.5 h from stroke onset were enrolled in this study. A logistic regression model was used to estimate the association between abnormal body mass index and 3-mo outcomes in stroke patients receiving IVT. The covariates included were screened using a least absolute shrinkage and selection operator regression model. In the meta-analysis, studies were searched in PubMed, Web of Science, and Embase databases from their inception to July 25, 2022. ResultsObesity, overweight, and underweight were not associated with 3-mo poor functional outcome compared with normal weight; the odds ratios and 95% CIs were 1.11 (0.64–1.92), 1.15 (0.86–1.54), and 0.57 (0.23–1.42), respectively. In addition, obesity was not associated with 3-mo poor functional outcome compared with non-obesity, and overweight or above was not associated with 3-mo poor functional outcome compared with non-overweight; the odds ratios and 95% CIs were 1.05 (0.62–1.77) and 1.18 (0.90–1.56), respectively. We obtained similar results for 3-mo mortality in patients with stroke. Similar results to the retrospective cohort study were obtained in the meta-analysis. ConclusionsOur results suggested that abnormal body mass index had no prognostic significance for the functional outcome or mortality of stroke patients at 3 mo after IVT.