Effect of a topical nonsteroidal anti-inflammatory agent (0.1% pranoprofen) on acute central serous chorioretinopathy.

Abstract

To investigate the effects of topical pranoprofen 0.1% on acute central serous chorioretinopathy (CSC). The medical records of 52 cases (52 patients) of CSC were retrospectively reviewed. Twenty-six patients were treated with topical pranoprofen 0.1% (treatment group) and 26 patients did not receive treatment (control group). Baseline and follow-up values for visual acuity, subfoveal choroidal thickness (SCT), subretinal fluid (SRF) maximum height, and central macular thickness (CMT) were examined and compared between groups. In the treatment group, mean SCT decreased from 365.5 ± 52.9μm at baseline to 288.9 ± 36.1μm at 6months after initiation of treatment (p = 0.005). Both SRF maximum height and CMT were also decreased from baseline at 1month (SRF maximum height, baseline: 221.5 ± 108.4, 1month: 97.7 ± 54.3μm, p = 0.002; CMT, baseline: 403.9 ± 114.6, 1month: 270.1 ± 37.9μm, p = 0.003). In the control group, SCT decreased throughout the follow-up period, but the change was not significant. Subretinal fluid maximum height and CMT were significantly decreased after 3months in the control group (SRF, baseline: 265.4 ± 112.4μm, 6months: 64.8 ± 116.9μm, p = 0.005; CMT, baseline: 459.1 ± 104.9μm, 6months: 304.6 ± 92.8μm, p < 0.001). Visual acuity was improved from baseline in both groups after 6months, but the improvement was only significant in the treatment group (p = 0.002). The rate of disease recurrence was lower in the treatment group (23%) than in the control group (38%), but this difference between groups was not statistically significant (p = 0.229, chi-square test). Topical pranoprofen 0.1% was effective in treating acute CSC, as demonstrated by an increase in visual acuity and a decrease in SRF, SCT, and CMT after treatment. These results suggest that topical pranoprofen 0.1% may be useful in treating patients with acute CSC.