Abstract
ROl-8307 (N-formyl-chitosan polysulfuric acid), a sulfated mucopolysaccharide with low anticoagulant activity, has been shown, in a dose of 80 mg/kg, to produce marked reduction in the width of the zona glomerulosa of the rat adrenal gland without apparent effect on the other zones. This selective effect of ROl-8307 suggests that the compound may be a useful tool in the study of adrenocortical function. (Endocrinology 78: 651,1966) T NATRIURETIC effect of heparin and other sulfated mucopolysaccharides is largely due to their ability to lower aldos^ terone secretion (1-4). No influence of these substances on urinary 17-ketosteroids and 17-hydroxycorticoids has been observed (1, Received October 1, 1965. Supported by grants from the Ontario Heart Foundation and the Medical Research Council of Canada. 4). The failure of heparin and ROl-8307 (Hoffmann-LaRoche designation for Nformyl-chitosan polysulfuric acid) to suppress aldosterone synthesis when added to rat adrenal slices has been cited as evidence of an indirect effect of these compounds on the adrenal cortex (5). Evidence against their acting via the renin-angiotensin control mechanism for aldosterone is the finding that ROl-8307 can reduce aldosterone secretion in cases of primary aldosteronism (6, 7) where 652 NOTES AND COMMENTS Volume 78
Published Version
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