Abstract
The results of studies on the biological influence of magnetic fields are controversial and do not provide clear answers regarding their impact on cell functioning. Fluoride compounds are substances that influence free radical processes, which occur when the reactive forms of oxygen are present. It is not known whether static magnetic fields (SMF) cause any changes in fluoride assimilation or activity. Therefore, the aim of this work was to determine the potential relationship between magnetic field exposure to, and the antioxidant system of, fibroblasts cultured with fluoride ions. Three chambers with static magnetic fields of different intensities (0.4, 0.6, and 0.7 T) were used in this work. Fluoride ions were added at a concentration of 0.12 mM, which did not cause the precipitation of calcium or magnesium. The results of this study show that static magnetic fields reduce the oxidative stress caused by fluoride ions and normalize the activities of antioxidant enzymes, including superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase (CAT). Static magnetic fields modify the energy state of fibroblasts, causing an increase in the ATP concentration and a decrease in the MDA concentration. These results suggest that exposure to fluoride and an SMF improves the tolerance of cells to the oxidative stress induced by fluoride ions.
Highlights
As civilization becomes more advanced, people are increasingly exposed to artificial magnetic fields (MFs)
Štolfy et al [8] demonstrated that human chondrocytes (HCH) subjected to an static magnetic fields (SMF) with a flux density of 0.6 T show an increase in viability
The aim of the present study was to determine the potential relationship between magnetic field exposure and the antioxidant system of fibroblasts cultured with fluoride ions
Summary
As civilization becomes more advanced, people are increasingly exposed to artificial magnetic fields (MFs). The results of previous studies conducted on this topic, both in vivo and in vitro, are controversial and do not provide a clear answer regarding the impact of magnetic fields on cell functioning [1,2,3]. This lack of clarity is due to the use of magnetic fields of different intensities and different cell types. Its concentration controls life processes as different as cyclic nucleotide levels, hormone and neurotransmitter secretion, growth, differentiation, and death Both induced and spontaneous apoptosis have been reported to be influenced by SMF exposure. The aim of the present study was to determine the potential relationship between magnetic field exposure and the antioxidant system of fibroblasts cultured with fluoride ions
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